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Glucagen Hypokit Prescribing Information

This information is not for clinical use. These highlights do not include all the information needed to use Glucagen Hypokit safely and effectively. Before taking Glucagen Hypokit please consult with your doctor. See full prescribing information for Glucagen Hypokit.

Indications And Usage

GlucaGen is an antihypoglycemic agent and a gastrointestinal motility inhibitor indicated for: •Treatment of severe hypoglycemia (1.1) •Use as a diagnostic aid (1.2) 1.1 Treatment of severe hypoglycemia GlucaGen is used to treat severe hypoglycemic (low blood sugar) reactions which may occur in patients with diabetes mellitus treated with insulin. Because GlucaGen depletes glycogen stores, the patient should be given supplemental carbohydrates as soon as he/she awakens and is able to swallow, especially children or adolescents. Medical evaluation is recommended for all patients who experience severe hypoglycemia. 1.2 Use as a diagnostic aid GlucaGen is indicated for use during radiologic examinations to temporarily inhibit movement of the gastrointestinal tract. Glucagon is as effective for this examination as are the anticholinergic drugs. However, the addition of the anticholinergic agent may result in increased side effects. After the end of the diagnostic procedure, give oral carbohydrates to patients who have been fasting, if this is compatible with the diagnostic procedure applied.

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Dosage Forms And Strengths

GlucaGen is supplied in a vial, alone, or accompanied by Sterile Water for Reconstitution (1 mL) also in a vial (10 pack or diagnostic kit). It is also supplied as GlucaGen HypoKit®, a presentation with a disposable prefilled syringe containing 1 mL Sterile Water for Reconstitution. When the glucagon powder is reconstituted with Sterile Water for Reconstitution (if supplied) or with Sterile Water for Injection, USP, it forms a solution of 1 mg/mL (1 unit/mL) glucagon for subcutaneous, intramuscular, or intravenous injection. •Each vial contains 1 mg/mL (1 unit/mL) GlucaGen when reconstituted with Sterile Water for Reconstitution or Sterile Water for Injection, USP. (3)

Contraindications

GlucaGen is contraindicated in patients with: •Known hypersensitivity to glucagon, lactose or any other constituent in GlucaGen •Pheochromocytoma [see Warnings and Precautions (5.1)] •Insulinoma [see Warnings and Precautions (5.2)] •Do not use in patients with known hypersensitivity to glucagon or lactose (4) •Do not use in patients with pheochromocytoma (4) •Do not use in patients with insulinoma (4)

Warning and Cautions

•Administer cautiously to patients suspected of having pheochromocytoma, insulinoma or glucagonoma due to risk of secondary hypoglycemia. Glucagon may release catecholamines from pheochromocytomas and is contraindicated in patients with this condition. (5.1, 5.2) •Allergic reactions may occur and include generalized rash, and in rare cases anaphylactic shock with breathing difficulties, and hypotension. (5.3) •In order for GlucaGen treatment to reverse hypoglycemia, there must be adequate amounts of glycogen stored in the liver. GlucaGen should be used with caution in patients with conditions resulting in low levels of releasable glucose in the liver. (5.4) •Use caution when glucagon is used as a diagnostic aid in diabetic patients because it may cause hyperglycemia. (5.4) •Use with caution in patients with known cardiac disease, as glucagon increases myocardial oxygen demand. (5.5) 5.1 Pheochromocytoma Glucagon is contraindicated in patients with pheochromocytoma because Glucagon may stimulate the release of catecholamines from the tumor. If the patient develops a dramatic increase in blood pressure, 5 to 10 mg of phentolamine mesylate has been shown to be effective in lowering blood pressure for the short time that control would be needed. 5.2 Insulinoma and Glucagonoma GlucaGen should be administered cautiously to patients suspected of having insulinoma or glucagonoma. In patients with insulinoma, intravenous administration of glucagon may produce an initial increase in blood glucose; however, glucagon administration may directly or indirectly (through an initial rise in blood glucose) stimulate exaggerated insulin release from an insulinoma. A patient developing symptoms of hypoglycemia after a dose of glucagon should be given glucose orally or intravenously, whichever is most appropriate. Caution should also be observed in administering GlucaGen to patients with glucagonoma. 5.3 Hypersensitivity and Allergic Reactions Allergic reactions may occur and include generalized rash, and in some cases anaphylactic shock with breathing difficulties, and hypotension. The anaphylactic reactions have generally occurred in association with endoscopic examination during which patients often received other agents including contrast media and local anesthetics. The patients should be given standard treatment for anaphylaxis including an injection of epinephrine if they encounter respiratory difficulties after GlucaGen injection. 5.4 Glycogen Stores and Hypoglycemia In order for GlucaGen treatment to reverse hypoglycemia, adequate amounts of glucose must be stored in the liver (as glycogen). Therefore, GlucaGen should be used with caution in patients with conditions such as prolonged fasting, starvation, adrenal insufficiency or chronic hypoglycemia because these conditions result in low levels of releasable glucose in the liver and an inadequate reversal of hypoglycemia by GlucaGen treatment. 5.5 Cardiac Disease Caution should be observed when glucagon is used as an adjunct in endoscopic or radiographic procedures to inhibit gastrointestinal motility in patients with known cardiac disease. 5.6 Laboratory Tests Blood glucose measurements may be considered to monitor the patient’s response.

Adverse Reactions

Side effects may include nausea and vomiting at doses above 1 mg or with rapid injection. Hypotension has been reported up to 2 hours after administration in patients receiving GlucaGen as premedication for upper GI endoscopy procedures. Glucagon exerts positive inotropic and chronotropic effects and may, therefore, cause tachycardia and hypertension. Adverse reactions indicating toxicity of GlucaGen have not been reported. A temporary increase in both blood pressure and pulse rate may occur following the administration of glucagon. Patients taking beta-blockers might be expected to have a greater increase in both pulse and blood pressure, an increase of which will be temporary because of glucagon’s short half-life [see Drug Interactions (7.1)] . The increase in blood pressure and pulse rate may require therapy in patients with pheochromocytoma or coronary artery disease [see Warnings and Precautions (5.1)]. Anaphylactic reactions may occur in some cases [see Warnings and Precautions (5.3)] . The following adverse reactions have been identified during postapproval use of GlucaGen. Because these adverse reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency. Table 1 Frequency of Adverse Reactions Treatment of severe hypoglycemia Frequency (%) Adverse Reaction < 10 Nausea < 1 Vomiting Use as a diagnostic aid < 10 Nausea < 1 Vomiting < 1 Hypoglycemia <1 Hypoglycemic coma Adverse reactions seen with GlucaGen are: •Nausea and vomiting (6) •Temporary increase in blood pressure and pulse may occur after administration. (6) To report SUSPECTED ADVERSE REACTIONS, contact Novo Nordisk Inc. at 1-800-727-6500 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

Drug Interactions

•Beta-blockers may cause a greater increase in both pulse and blood pressure after administration. (7.1) •Glucagon may lose its ability to raise blood glucose or may produce hypoglycemia when given with indomethacin. (7.2) •Coadministration with an anticholinergic drug is not recommended due to increased gastrointestinal side effects. (7.3) •Glucagon may increase the anticoagulant effect of warfarin. (7.4) •Insulin reacts antagonistically towards glucagon. (7.5) 7.1 Beta-blockers Patients taking beta-blockers might be expected to have a greater increase in both pulse and blood pressure, an increase of which will be temporary because of glucagon’s short half-life. The increase in blood pressure and pulse rate may require therapy in patients with pheochromocytoma or coronary artery disease. 7.2 Indomethacin When used with indomethacin, glucagon may lose its ability to raise blood glucose or may even produce hypoglycemia. Therefore, caution should be exercised for patients taking indomethacin when glucagon will be administered. 7.3 Anticholinergic Drugs Coadministration with an anticholinergic drug is not recommended due to increased gastrointestinal side effects. 7.4 Warfarin Glucagon may increase the anticoagulant effect of warfarin. Therefore, caution should be exercised for patients taking warfarin when glucagon will be administered. 7.5 Insulin Insulin reacts antagonistically towards glucagon. Therefore, caution should be exercised when glucagon is used as a diagnostic aid in diabetes patients.

Use In Specific Populations

•Nursing mothers: unknown whether drug is excreted in human milk, therefore caution should be exercised. (8.3) •Pediatrics: reported safe and effective for treatment of hypoglycemia. Safety and effectiveness for use as a diagnostic aid have not been established. (8.4) 8.1 Pregnancy Pregnancy Category B. Reproduction studies were performed in rats and rabbits at GlucaGen doses of 0.4, 2.0, and 10 mg/kg. These doses represent exposures of up to 100 and 200 times the human dose based on mg/m2 for rats and rabbits, respectively, and revealed no evidence of harm to the fetus. There are, however, no adequate and well-controlled studies in pregnant women. Glucagon does not cross the human placenta barrier. 8.3 Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when GlucaGen is administered to a nursing woman. No clinical studies have been performed in nursing mothers, however, GlucaGen is a peptide and intact glucagon is not absorbed from the GI tract. Therefore, even if the infant ingested glucagon it would be unlikely to have any effect on the infant. Additionally, GlucaGen has a short plasma half-life thus limiting amounts available to the child. Glucagon does not cross the human placental barrier. 8.4 Pediatric Use For the treatment of severe hypoglycemia: The use of glucagon in pediatric patients has been reported to be safe and effective. For use as a diagnostic aid: Safety and effectiveness in pediatric patients have not been established.

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