INDICATIONS AND USAGE For the treatment of hypoglycemia: Glucagon is indicated as a treatment for severe hypoglycemia. Because patients with type 1 diabetes may have less of an increase in blood glucose levels compared with a stable type 2 patient, supplementary carbohydrate should be given as soon as possible, especially to a pediatric patient. For use as a diagnostic aid: Glucagon is indicated as a diagnostic aid in the radiologic examination of the stomach, duodenum, small bowel, and colon when diminished intestinal motility would be advantageous. Glucagon is as effective for this examination as are the anticholinergic drugs. However, the addition of the anticholinergic agent may result in increased side effects.
| * Administration of 2 mg (2 units) doses produces a higher incidence of nausea and vomiting than do lower doses. |
|Dose ||Route of Administration ||Time of Onset of Action ||Approximate Duration of Effect |
|0.25-0.5 mg (0.25-0.5 units) ||IV ||1 minute ||9-17 minutes |
|1-mg (1 unit) ||IM ||8-10 minutes ||12-27 minutes |
|2 mg* (2 units) ||IV ||1 minute ||22-25 minutes |
|2 mg* (2 units) ||IM ||4-7 minutes ||21-32 minutes |
CONTRAINDICATIONS Glucagon is contraindicated in patients with known hypersensitivity to it or in patients with known pheochromocytoma.
ADVERSE REACTIONS Severe adverse reactions are very rare, although nausea and vomiting may occur occasionally. These reactions may also occur with hypoglycemia. Generalized allergic reactions have been reported (see WARNINGS). In a three month controlled study of 75 volunteers comparing animal-sourced glucagon with glucagon manufactured through rDNA technology, no glucagon-specific antibodies were detected in either treatment group.