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Lidocaine-prilocaine Prescribing Information

This information is not for clinical use. These highlights do not include all the information needed to use Lidocaine-prilocaine safely and effectively. Before taking Lidocaine-prilocaine please consult with your doctor. See full prescribing information for Lidocaine-prilocaine.

Indications And Usage

Compounded Lidocaine-Prilocaine-Cream Base (a eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is indicated as a topical anesthetic for use on: normal intact skin for local analgesia. genital mucous membranes for superficial minor surgery and as pretreatment for infiltration anesthesia. Compounded Lidocaine-Prilocaine-Cream Base is not recommended in any clinical situation when penetration or migration beyond the tympanic membrane into the middle ear is possible because of the ototoxic effects observed in animal studies (see WARNINGS).

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Contraindications

Compounded Lidocaine-Prilocaine-Cream Base (lidocaine 2.5% and prilocaine 2.5%) is contraindicated in patients with a known history of sensitivity to local anesthetics of the amide type or to any other component of the product.

Adverse Reactions

Localized Reactions: During or immediately after treatment with Compounded Lidocaine-Prilocaine-Cream Base on intact skin, the skin at the site of treatment may develop erythema or edema or may be the locus of abnormal sensation. Rare cases of discrete purpuric or petechial reactions at the application site have been reported. Rare cases of hyperpigmentation following the use of Lidocaine-Prilocaine-Cream Base have been reported. The relationship to Lidocaine-Prilocaine-Cream Base or the underlying procedure has not been established. In clinical studies on intact skin involving over 1,300 Lidocaine-Prilocaine-Cream Base-treated subjects, one or more such local reactions were noted in 56% of patients, and were generally mild and transient, resolving spontaneously within 1 or 2 hours. There were no serious reactions that were ascribed to Lidocaine-Prilocaine-Cream Base. Two recent reports describe blistering on the foreskin in neonates about to undergo circumcision. Both neonates received 1.0 g of Lidocaine-Prilocaine-Cream Base. In patients treated with Lidocaine-Prilocaine-Cream Base on intact skin, local effects observed in the trials included: paleness (pallor or blanching) 37%, redness (erythema) 30%, alterations in temperature sensations 7%, edema 6%, itching 2% and rash, less than 1%. In clinical studies on genital mucous membranes involving 378 Lidocaine-Prilocaine-Cream Base-treated patients, one or more application site reactions, usually mild and transient, were noted in 41% of patients. The most common application site reactions were redness (21%), burning sensation (17%) and edema (10%). Allergic Reactions: Allergic and anaphylactoid reactions associated with lidocaine or prilocaine can occur. They are characterized by urticaria, angioedema, bronchospasm, and shock. If they occur they should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value. Systemic (Dose Related) Reactions: Systemic adverse reactions following appropriate use of Compounded Lidocaine-Prilocaine-Cream Base are unlikely due to the small dose absorbed (see Pharmacokinetics subsection of CLINICAL PHARMACOLOGY). Systemic adverse effects of lidocaine and/or prilocaine are similar in nature to those observed with other amide local anesthetic agents including CNS excitation and/or depression (light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest). Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness merging into unconsciousness. Cardiovascular manifestations may include bradycardia, hypotension and cardiovascular collapse leading to arrest.

Drug Interactions

Drug Interactions: Compounded Lidocaine-Prilocaine-Cream Base should be used with caution in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine) since the toxic effects are additive and potentially synergistic. Prilocaine may contribute to the formation of methemoglobin in patients treated with other drugs known to cause this condition (see Methemoglobinemia subsection of WARNINGS). Specific interaction studies with lidocaine/prilocaine and class III anti-arrhythmic drugs (e.g., amiodarone, bretylium, sotalol, doetilide) have not been performed, but caution is advised (see WARNINGS). Should Compounded Lidocaine-Prilocaine-Cream Base be used concomitantly with other products containing lidocaine and/or prilocaine, cumulative doses from all formulations must be considered.

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