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Estimated Savings Of Over $9,832,927

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Pomalyst prescribing information
This information is not for clinical use. These highlights do not include all the information needed to use Pomalyst safely and effectively.
Before taking Pomalyst please consult with your doctor. See full prescribing information for Pomalyst.
WARNING: EMBRYO-FETAL TOXICITY and VENOUS AND ARTERIAL THROMBOEMBOLISM Embryo-Fetal Toxicity POMALYST is contraindicated in pregnancy. POMALYST is a thalidomide analogue. Thalidomide is a known human teratogen that causes severe birth defects or embryo-fetal death. In females of reproductive potential, obtain 2 negative pregnancy tests before starting POMALYST treatment. Females of reproductive potential must use 2 forms of contraception or continuously abstain from heterosexual sex during and for 4 weeks after stopping POMALYST treatment [see Contraindications (4), Warnings and Precautions (5.1), and Use in Specific Populations (8.1, 8.6)]. POMALYST is only available through a restricted distribution program called POMALYST REMS [see Warnings and Precautions (5.2)]. Venous and Arterial Thromboembolism Deep venous thrombosis (DVT), pulmonary embolism (PE), myocardial infarction, and stroke occur in patients with multiple myeloma treated with POMALYST. Prophylactic antithrombotic measures were employed in clinical trials. Thromboprophylaxis is recommended, and the choice of regimen should be based on assessment of the patient's underlying risk factors [see Warnings and Precautions (5.3)]. WARNING: EMBRYO-FETAL TOXICITY and VENOUS AND ARTERIAL THROMBOEMBOLISM See full prescribing information for complete boxed warning EMBRYO-FETAL TOXICITY POMALYST is contraindicated in pregnancy. POMALYST is a thalidomide analogue. Thalidomide is a known human teratogen that causes severe life-threatening birth defects (4, 5.1, 8.1). For females of reproductive potential: Exclude pregnancy before start of treatment. Prevent pregnancy during treatment by the use of 2 reliable methods of contraception (5.1, 8.6). POMALYST is available only through a restricted program called POMALYST REMS® (5.2). VENOUS AND ARTERIAL THROMBOEMBOLISM Deep venous thrombosis (DVT), pulmonary embolism (PE), myocardial infarction, and stroke occur in patients with multiple myeloma treated with POMALYST. Antithrombotic prophylaxis is recommended (5.3).
Boxed Warning 04/15
Indications and Usage (1.1) 04/15
Dosage and Administration (2.1, 2.2) 04/15
Warnings and Precautions (5.3, 5.4, 5.5, 5.6, 5.7, 5.8) 04/15
Warnings and Precautions (5.10) 05/14
1 INDICATIONS AND USAGE POMALYST is a thalidomide analogue indicated, in combination with dexamethasone, for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy (1.1). 1.1 Multiple Myeloma POMALYST, in combination with dexamethasone, is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy.
Table 1: Dose Modification Instructions for POMALYST for Hematologic Toxicities
ANC, absolute neutrophil count
Toxicity Dose Modification
Neutropenia ANC <500 per mcL or febrile neutropenia (fever more than or equal to 38.5°C and ANC <1,000 per mcL) ANC return to more than or equal to 500 per mcL Interrupt POMALYST treatment, follow CBC weekly Resume POMALYST treatment at 3 mg daily
For each subsequent drop <500 per mcL Return to more than or equal to 500 per mcL Interrupt POMALYST treatment Resume POMALYST treatment at 1 mg less than the previous dose
Thrombocytopenia Platelets <25,000 per mcL Platelets return to >50,000 per mcL Interrupt POMALYST treatment, follow CBC weekly Resume POMALYST treatment at 3 mg daily
For each subsequent drop <25,000 per mcL Return to more than or equal to 50,000 per mcL Interrupt POMALYST treatment Resume POMALYST treatment at 1 mg less than previous dose
3 DOSAGE FORMS AND STRENGTHS POMALYST is available in the following capsule strengths: 1 mg: Dark blue opaque cap and yellow opaque body, imprinted “POML” on the cap in white ink and “1 mg” on the body in black ink 2 mg: Dark blue opaque cap and orange opaque body, imprinted “POML” on the cap and “2 mg” on the body in white ink 3 mg: Dark blue opaque cap and green opaque body, imprinted “POML” on the cap and “3 mg” on the body in white ink 4 mg: Dark blue opaque cap and blue opaque body, imprinted “POML” on the cap and “4 mg” on the body in white ink Capsules: 1 mg, 2 mg, 3 mg, and 4 mg (3)
4 CONTRAINDICATIONS Pregnancy (4) Pregnancy POMALYST can cause fetal harm when administered to a pregnant female [see Warnings and Precautions (5.1) and Use in Specific Populations (8.1)]. POMALYST is contraindicated in females who are pregnant. Pomalidomide is a thalidomide analogue and is teratogenic in both rats and rabbits when administered during the period of organogenesis. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus.
5 WARNINGS AND PRECAUTIONS Hematologic Toxicity: Neutropenia was the most frequently reported Grade 3/4 adverse event. Monitor patients for hematologic toxicities, especially neutropenia (5.4). Hepatotoxicity: Hepatic failure including fatalities; monitor liver function tests monthly (5.5). Hypersensitivity Reactions: Angioedema and severe dermatologic reactions have been reported. Discontinue POMALYST for angioedema and severe dermatologic reactions (5.6). Tumor Lysis Syndrome (TLS): Monitor patients at risk of TLS (i.e., those with high tumor burden) and take appropriate precautions (5.10). 5.1 Embryo-Fetal Toxicity POMALYST is a thalidomide analogue and is contraindicated for use during pregnancy. Thalidomide is a known human teratogen that causes severe birth defects or embryo-fetal death [see Use in Specific Populations (8.1)]. POMALYST is only available through the POMALYST REMS program [see Warnings and Precautions (5.2)]. Females of Reproductive Potential Females of reproductive potential must avoid pregnancy while taking POMALYST and for at least 4 weeks after completing therapy. Females must commit either to abstain continuously from heterosexual sexual intercourse or to use 2 methods of reliable birth control, beginning 4 weeks prior to initiating treatment with POMALYST, during therapy, during dose interruptions, and continuing for 4 weeks following discontinuation of POMALYST therapy. Two negative pregnancy tests must be obtained prior to initiating therapy. The first test should be performed within 10-14 days and the second test within 24 hours prior to prescribing POMALYST therapy and then weekly during the first month, then monthly thereafter in women with regular menstrual cycles, or every 2 weeks in women with irregular menstrual cycles [see Use in Specific Populations (8.6)]. Males Pomalidomide is present in the semen of patients receiving the drug. Therefore, males must always use a latex or synthetic condom during any sexual contact with females of reproductive potential while taking POMALYST and for up to 28 days after discontinuing POMALYST, even if they have undergone a successful vasectomy. Male patients taking POMALYST must not donate sperm [see Use in Specific Populations (8.6)]. Blood Donation Patients must not donate blood during treatment with POMALYST and for 1 month following discontinuation of the drug because the blood might be given to a pregnant female patient whose fetus must not be exposed to POMALYST. 5.2 POMALYST REMS Program Because of the embryo-fetal risk [see Warnings and Precautions (5.1)], POMALYST is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called “POMALYST REMS.” Required components of the POMALYST REMS program include the following: Prescribers must be certified with the POMALYST REMS program by enrolling and complying with the REMS requirements. Patients must sign a Patient-Physician Agreement Form and comply with the REMS requirements. In particular, female patients of reproductive potential who are not pregnant must comply with the pregnancy testing and contraception requirements [see Use in Specific Populations (8.6)] and males must comply with contraception requirements [see Use in Specific Populations (8.6)]. Pharmacies must be certified with the POMALYST REMS program, must only dispense to patients who are authorized to receive POMALYST, and comply with REMS requirements. Further information about the POMALYST REMS program is available at www.CelgeneRiskManagement.com or by telephone at 1-888-423-5436. 5.3 Venous and Arterial Thromboembolism Venous thromboembolic events (deep venous thrombosis and pulmonary embolism) and arterial thromboembolic events (myocardial infarction and stroke) have been observed in patients treated with POMALYST. In Trial 2, where anticoagulant therapies were mandated, thromboembolic events occurred in 8.0% of patients treated with POMALYST and low dose-dexamethasone (Low-dose Dex), and 3.3% of patients treated with high-dose dexamethasone. Venous thromboembolic events (VTE) occurred in 4.7% of patients treated with POMALYST and Low-dose Dex, and 1.3% of patients treated with high-dose dexamethasone. Arterial thromboembolic events include terms for arterial thromboembolic events, ischemic cerebrovascular conditions, and ischemic heart disease. Arterial thromboembolic events occurred in 3.0% of patients treated with POMALYST and Low-dose Dex, and 1.3% of patients treated with high-dose dexamethasone. Patients with known risk factors, including prior thrombosis, may be at greater risk, and actions should be taken to try to minimize all modifiable factors (e.g., hyperlipidemia, hypertension, smoking). Thromboprophylaxis is recommended, and the choice of regimen should be based on assessment of the patient's underlying risk factors. 5.4 Hematologic Toxicity In trials 1 and 2 in patients who received POMALYST + Low-dose Dex, neutropenia was the most frequently reported Grade 3/4 adverse reaction, followed by anemia and thrombocytopenia. Neutropenia of any grade was reported in 51% of patients in both trials. The rate of Grade 3/4 neutropenia was 46%. The rate of febrile neutropenia was 8%. Monitor patients for hematologic toxicities, especially neutropenia. Monitor complete blood counts weekly for the first 8 weeks and monthly thereafter. Patients may require dose interruption and/or modification [see Dosage and Administration (2.2)]. 5.5 Hepatotoxicity Hepatic failure, including fatal cases, has occurred in patients treated with POMALYST. Elevated levels of alanine aminotransferase and bilirubin have also been observed in patients treated with POMALYST. Monitor liver function tests monthly. Stop POMALYST upon elevation of liver enzymes and evaluate. After return to baseline values, treatment at a lower dose may be considered. 5.6 Hypersensitivity Reactions Angioedema and severe dermatologic reactions have been reported. Discontinue POMALYST for angioedema, skin exfoliation, bullae, or any other severe dermatologic reactions, and do not resume therapy [see Dosage and Administration (2.2)]. 5.7 Dizziness and Confusional State In trials 1 and 2 in patients who received POMALYST + Low-dose Dex, 14% of patients experienced dizziness and 7% of patients experienced a confusional state; 1% of patients experienced Grade 3 or 4 dizziness, and 3% of patients experienced Grade 3 or 4 confusional state. Instruct patients to avoid situations where dizziness or confusional state may be a problem and not to take other medications that may cause dizziness or confusional state without adequate medical advice. 5.8 Neuropathy In trials 1 and 2 in patients who received POMALYST + Low-dose Dex, 18% of patients experienced neuropathy, with approximately 12% of the patients experiencing peripheral neuropathy. Two percent of patients experienced Grade 3 neuropathy in trial 2. There were no cases of Grade 4 neuropathy adverse reactions reported in either trial. 5.9 Risk of Second Primary Malignancies Cases of acute myelogenous leukemia have been reported in patients receiving POMALYST as an investigational therapy outside of multiple myeloma. 5.10 Tumor Lysis Syndrome Tumor lysis syndrome (TLS) may occur in patients treated with pomalidomide. Patients at risk for TLS are those with high tumor burden prior to treatment. These patients should be monitored closely and appropriate precautions taken.
6 ADVERSE REACTIONS The following adverse reactions are described in detail in other labeling sections: Fetal Risk [see Boxed Warnings, Warnings and Precautions (5.1, 5.2)] Venous and Arterial Thromboembolism [see Boxed Warnings, Warnings and Precautions (5.3)] Hematologic Toxicity [see Warnings and Precautions (5.4)] Hepatotoxicity [see Warnings and Precautions (5.5)] Hypersensitivity Reactions [see Warnings and Precautions (5.6)] Dizziness and Confusional State [see Warnings and Precautions (5.7)] Neuropathy [see Warnings and Precautions (5.8)] Risk of Second Primary Malignancies [see Warnings and Precautions (5.9)] Tumor Lysis Syndrome [see Warnings and Precautions (5.10)] Most common adverse reactions (≥30%) included fatigue and asthenia, neutropenia, anemia, constipation, nausea, diarrhea, dyspnea, upper-respiratory tract infections, back pain and pyrexia (6.1). To report SUSPECTED ADVERSE REACTIONS, contact Celgene Corporation at 1-888-423-5436 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Multiple Myeloma Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. In Trial 1, data were evaluated from 219 patients (safety population) who received treatment with POMALYST + Low-dose Dex (112 patients) or POMALYST alone (107 patients). Median number of treatment cycles was 5. Sixty-seven percent of patients in the study had a dose interruption of either drug due to adverse reactions. Forty-two percent of patients in the study had a dose reduction of either drug due to adverse reactions. The discontinuation rate due to adverse reactions was 11%. In Trial 2, data were evaluated from 450 patients (safety population) who received treatment with POMALYST + Low-dose Dex (300 patients) or High-dose Dexamethasone (High-dose Dex) (150 patients). The median number of treatment cycles for the POMALYST + Low-dose Dex arm was 5. In the POMALYST + Low-dose Dex arm, 67% of patients had a dose interruption of POMALYST, the median time to the first dose interruption of POMALYST was 4.1 weeks. Twenty-seven percent of patients had a dose reduction of POMALYST, the median time to the first dose reduction of POMALYST was 4.5 weeks. Eight percent of patients discontinued POMALYST due to adverse reactions. Tables 2 and 3 summarize the adverse reactions reported in Trials 1 and 2, respectively. Table 2: Adverse Reactions in Any POMALYST Treatment Arm in Trial 1* * Regardless of attribution of relatedness to POMALYST. a POMALYST alone arm includes all patients randomized to the POMALYST alone arm who took study drug; 61 of the 107 patients had dexamethasone added during the treatment period. b Serious adverse reactions were reported in at least 2 patients in any POMALYST treatment arm. Data cutoff: 01 March 2013 All Adverse Reactions ≥10% in Either Arm Grade 3 or 4 ≥5% in Either Arm System Organ Class/Preferred Term POMALYSTa (N=107) POMALYST + Low-dose Dex (N=112) POMALYST (N=107) POMALYST + Low-dose Dex (N=112) Number (%) of patients with at least one adverse reaction 107 (100) 112 (100) 98 (91.6) 102 (91.1) Blood and lymphatic system disorders Neutropenia b 57 (53.3) 55 (49.1) 51 (47.7) 46 (41.1) Anemia b 41 (38.3) 47 (42.0) 25 (23.4) 24 (21.4) Thrombocytopenia b 28 (26.2) 26 (23.2) 24 (22.4) 21 (18.8) Leukopenia 14 (13.1) 22 (19.6) 7 (6.5) 11 (9.8) Febrile neutropenia b <10% <10% 6 (5.6) 3 (2.7) Lymphopenia 4 (3.7) 17 (15.2) 2 (1.9) 8 (7.1) General disorders and administration site conditions Fatigue and asthenia b 62 (57.9) 70 (62.5) 13 (12.1) 19 (17.0) Edema peripheral 27 (25.2) 19 (17.0) 0 (0.0) 0 (0.0) Pyrexia b 25 (23.4) 36 (32.1) <5% <5% Chills 11 (10.3) 14 (12.5) 0 (0.0) 0 (0.0) Gastrointestinal disorders Nausea b 39 (36.4) 27 (24.1) <5% <5% Constipation b 38 (35.5) 41 (36.6) <5% <5% Diarrhea 37 (34.6) 40 (35.7) <5% <5% Vomiting b 15 (14.0) 16 (14.3) <5% 0 (0.0) Musculoskeletal and connective tissue disorders Back pain b 37 (34.6) 36 (32.1) 15 (14.0) 11 (9.8) Musculoskeletal chest pain 25 (23.4) 22 (19.6) <5% 0 (0.0) Muscle spasms 23 (21.5) 22 (19.6) <5% <5% Arthralgia 18 (16.8) 17 (15.2) <5% <5% Muscular weakness 15 (14.0) 15 (13.4) 6 (5.6) 4 (3.6) Bone pain 13 (12.1) 8 (7.1) <5% <5% Musculoskeletal pain 13 (12.1) 19 (17.0) <5% <5% Pain in extremity 8 (7.5) 16 (14.3) 0 (0.0) <5% Infections and infestations Upper respiratory tract infection 40 (37.4) 32 (28.6) <5% <5% Pneumonia b 30 (28.0) 38 (33.9) 21 (19.6) 32 (28.6) Urinary tract infection b 11 (10.3) 19 (17.0) 2 (1.9) 10 (8.9) Sepsis b <10% <10% 6 (5.6) 5 (4.5) Metabolism and nutrition disorders Decreased appetite 25 (23.4) 21 (18.8) <5% 0 (0.0) Hypercalcemia b 23 (21.5) 13 (11.6) 11 (10.3) 1 (0.9) Hypokalemia 13 (12.1) 13 (11.6) <5% <5% Hyperglycemia 12 (11.2) 17 (15.2) <5% <5% Hyponatremia 12 (11.2) 14 (12.5) <5% <5% Dehydration b <10% <10% 5 (4.7) 6 (5.4) Hypocalcemia 6 (5.6) 13 (11.6) 0 (0.0) <5% Respiratory, thoracic and mediastinal disorders Dyspnea b 38 (35.5) 50 (44.6) 8 (7.5) 14 (12.5) Cough 18 (16.8) 25 (22.3) 0 (0.0) 0 (0.0) Epistaxis 18 (16.8) 12 (10.7) <5% 0 (0.0) Productive cough 10 (9.3) 14 (12.5) 0 (0.0) 0 (0.0) Oropharyngeal pain 6 (5.6) 12 (10.7) 0 (0.0) 0 (0.0) Nervous system disorders Dizziness 24 (22.4) 20 (17.9) <5% <5% Peripheral neuropathy 23 (21.5) 20 (17.9) 0 (0.0) 0 (0.0) Headache 16 (15.0) 15 (13.4) 0 (0.0) <5% Tremor 11 (10.3) 15 (13.4) 0 (0.0) 0 (0.0) Skin and subcutaneous tissue disorders Rash 22 (20.6) 18 (16.1) 0 (0.0) <5% Pruritus 16 (15.0) 10 (8.9) 0 (0.0) 0 (0.0) Dry skin 10 (9.3) 12 (10.7) 0 (0.0) 0 (0.0) Hyperhidrosis 8 (7.5) 18 (16.1) 0 (0.0) 0 (0.0) Night sweats 5 (4.7) 14 (12.5) 0 (0.0) 0 (0.0) Investigations Blood creatinine increased b 20 (18.7) 11 (9.8) 6 (5.6) 3 (2.7) Weight decreased 16 (15.0) 10 (8.9) 0 (0.0) 0 (0.0) Weight increased 1 (0.9) 12 (10.7) 0 (0.0) 0 (0.0) Psychiatric disorders Anxiety 14 (13.1) 8 (7.1) 0 (0.0) 0 (0.0) Confusional state b 13 (12.1) 15 (13.4) 6 (5.6) 3 (2.7) Insomnia 7 (6.5) 18 (16.1) 0 (0.0) 0 (0.0) Renal and urinary disorders Renal failure b 16 (15.0) 11 (9.8) 9 (8.4) 8 (7.1) Table 3: Adverse Reactions in Trial 2 a Percentage did not meet the criteria to be considered as an adverse reaction for POMALYST for that category of event (i.e., all adverse events or Grade 3 or 4 adverse events). b Serious adverse reactions were reported in at least 3 patients in the POM + Low-dose Dex arm, AND at least 1% higher than the High-dose-Dex arm percentage. Data cutoff: 01 March 2013 All Adverse Reactions (≥5% in POMALYST + Low-dose Dex arm, and at least 2% point higher than the High-dose-Dex arm) Grade 3 or 4 (≥1% in POMALYST + Low-dose Dex arm, and at least 1% point higher than the High-dose-Dex arm) System Organ Class/Preferred Term POMALYST + Low-dose Dex (N=300) High-dose Dex (N=150) POMALYST + Low-dose Dex (N=300) High-dose Dex (N=150) Number (%) of patients with at least one adverse reaction 297 (99.0) 149 (99.3) 259 (86.3) 127 (84.7) Blood and lymphatic system disorders Neutropenia b 154 (51.3) 31 (20.7) 145 (48.3) 24 (16.0) Thrombocytopenia 89 (29.7) a 44 (29.3) a 66 (22.0) a 39 (26.0) a Leukopenia 38 (12.7) 8 (5.3) 27 (9.0) 5 (3.3) Febrile neutropenia b 28 (9.3) 0 (0.0) 28 (9.3) 0 (0.0) General disorders and administration site conditions Fatigue and asthenia 140 (46.7) 64 (42.7) 26 (8.7) a 18 (12.0) a Pyrexia b 80 (26.7) 35 (23.3) 9 (3.0) a 7 (4.7) a Edema peripheral 52 (17.3) 17 (11.3) 4 (1.3) a 3 (2.0) a Pain 11 (3.7) a 3 (2.0) a 5 (1.7) 1 (0.7) Infections and infestations Upper respiratory tract infection b 93 (31.0) 19 (12.7) 9 (3.0) 1 (0.7) Pneumonia b 58 (19.3) 20 (13.3) 47 (15.7) 15 (10.0) Neutropenic sepsis b 3 (1.0) a 0 (0.0) a 3 (1.0) 0 (0.0) Gastrointestinal disorders Diarrhea 66 (22.0) 28 (18.7) 3 (1.0) a 2 (1.3) a Constipation 65 (21.7) 22 (14.7) 7 (2.3) 0 (0.0) Nausea 45 (15.0) 17 (11.3) 3 (1.0) a 2 (1.3) a Vomiting 23 (7.7) 6 (4.0) 3 (1.0) 0 (0.0) Musculoskeletal and connective tissue disorders Back pain b 59 (19.7) 24 (16.0) 15 (5.0) 6 (4.0) Bone pain b 54 (18.0) 21 (14.0) 22 (7.3) 7 (4.7) Muscle spasms 46 (15.3) 11 (7.3) 1 (0.3) a 1 (0.7) a Arthralgia 26 (8.7) 7 (4.7) 2 (0.7) a 1 (0.7) a Pain in extremity 20 (6.7) a 9 (6.0) a 6 (2.0) 0 (0.0) Respiratory, thoracic and mediastinal disorders Dyspnea b 76 (25.3) 25 (16.7) 17 (5.7) 7 (4.7) Cough 60 (20.0) 15 (10.0) 2 (0.7) a 1 (0.7) a Chronic obstructive pulmonary disease b 5 (1.7) a 0 (0.0) a 4 (1.3) 0 (0.0) Nervous system disorders Peripheral neuropathy 52 (17.3) 18 (12.0) 5 (1.7) a 2 (1.3) a Dizziness 37 (12.3) 14 (9.3) 4 (1.3) a 2 (1.3) a Headache 23 (7.7) 8 (5.3) 1 (0.3) a 0 (0.0) a Tremor 17 (5.7) 2 (1.3) 2 (0.7) a 0 (0.0) a Depressed level of consciousness 5 (1.7) a 0 (0.0) a 3 (1.0) 0 (0.0) Metabolism and nutrition disorders Decreased appetite 38 (12.7) 12 (8.0) 3 (1.0) a 2 (1.3) a Hypokalemia 28 (9.3) a 12 (8.0) a 12 (4.0) 4 (2.7) Hypocalcemia 12 (4.0) a 9 (6.0) a 5 (1.7) 1 (0.7) Skin and subcutaneous tissue disorders Rash 23 (7.7) 2 (1.3) 3 (1.0) 0 (0.0) Pruritus 22 (7.3) 5 (3.3) 0 (0.0) a 0 (0.0) a Hyperhidrosis 15 (5.0) 1 (0.7) 0 (0.0) a 0 (0.0) a Investigations Neutrophil count decreased 15 (5.0) 1 (0.7) 14 (4.7) 1 (0.7) Platelet count decreased 10 (3.3) a 3 (2.0) a 8 (2.7) 2 (1.3) White blood cell count decreased 8 (2.7) a 1 (0.7) a 8 (2.7) 0 (0.0) Alanine aminotransferase increased 7 (2.3) a 2 (1.3) a 5 (1.7) 0 (0.0) Aspartate aminotransferase increased 4 (1.3) a 2 (1.3) a 3 (1.0) 0 (0.0) Lymphocyte count decreased 3 (1.0) a 1 (0.7) a 3 (1.0) 0 (0.0) Renal and urinary disorders Renal failure 31 (10.3) a 18 (12.0) a 19 (6.3) 8 (5.3) Injury, poisoning and procedural complications Femur fracture b 5 (1.7) a 1 (0.7) a 5 (1.7) 1 (0.7) Reproductive system and breast disorders Pelvic pain 6 (2.0) a 3 (2.0) a 4 (1.3) 0 (0.0) Other Adverse Reactions Other adverse reactions of POMALYST in patients with multiple myeloma, not described above, and considered important: Cardiac disorders: Myocardial infarction, Atrial fibrillation, Angina pectoris, Cardiac failure congestive Ear and labyrinth disorders: Vertigo Gastrointestinal disorders: Abdominal pain General disorders and administration site conditions: General physical health deterioration, Non-cardiac chest pain, Multi-organ failure Hepatobiliary disorders: Hyperbilirubinemia Infections and infestations: Pneumocystis jiroveci pneumonia, Respiratory syncytial virus infection, Neutropenic sepsis, Bacteremia, Pneumonia respiratory syncytial viral, Cellulitis, Urosepsis, Septic shock, Clostridium difficile colitis, Pneumonia streptococcal, Lobar pneumonia, Viral infection, Lung infection Investigations: Alanine aminotransferase increased, Hemoglobin decreased Injury, poisoning and procedural complications: Fall, Compression fracture, Spinal compression fracture Metabolism and nutritional disorders: Hyperkalemia, Failure to thrive Nervous System disorders: Depressed level of consciousness, Syncope Psychiatric disorders: Mental status change Renal and urinary disorders: Urinary retention, Hyponatremia Reproductive system and breast disorders: Pelvic pain Respiratory, thoracic, and mediastinal disorders: Interstitial lung disease, Pulmonary embolism, Respiratory failure, Bronchospasm Vascular disorders: Hypotension 6.2 Postmarketing Experience The following adverse drug reactions have been identified from the worldwide postmarketing experience with POMALYST: Pancytopenia, tumor lysis syndrome, allergic reactions (e.g., angioedema, urticaria), elevated liver enzymes, hepatic failure (including fatal cases). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
7 DRUG INTERACTIONS Pomalidomide is primarily metabolized by CYP1A2 and CYP3A. Pomalidomide is also a substrate for P-glycoprotein (P-gp). Strong CYP1A2 Inhibitors: Avoid the use of strong CYP1A2 inhibitors unless medically necessary (2.3, 7.1, 12.3). 7.1 Drugs That May Increase Pomalidomide Plasma Concentrations CYP1A2 inhibitors: Pomalidomide exposure is increased when POMALYST is co-administered with a strong CYP1A2 inhibitor (fluvoxamine) in the presence of a strong CYP3A4/5 and P-gp inhibitor (ketoconazole). Ketoconazole in the absence of a CYP1A2 inhibitor does not increase pomalidomide exposure. Avoid co-administration of strong CYP1A2 inhibitors (e.g. ciprofloxacin and fluvoxamine) [see Dosage and Administration (2.3) and Clinical Pharmacology (12.3)]. If it is medically necessary to co-administer strong inhibitors of CYP1A2 in the presence of strong inhibitors of CYP3A4 and P-gp, POMALYST dose should be reduced by 50%. The effect of a CYP1A2 inhibitor in the absence of a co-administered CYP3A4 and P-gp inhibitor has not been studied. Monitor for toxicities if CYP1A2 inhibitors are to be co-administered in the absence of a co-administered CYP3A4 and P-gp inhibitor, and reduce dose if needed. 7.2 Drugs That May Decrease Pomalidomide Plasma Concentrations Smoking: Cigarette smoking may reduce pomalidomide exposure due to CYP1A2 induction. Patients should be advised that smoking may reduce the efficacy of pomalidomide. CYP1A2 inducers: Co-administration of POMALYST with drugs that are CYP1A2 inducers has not been studied and may reduce pomalidomide exposure.
8 USE IN SPECIFIC POPULATIONS Nursing Mothers: Discontinue drug or nursing taking into consideration importance of drug to mother (8.3). Avoid POMALYST in patients with serum creatinine >3.0 mg/dL (8.7). 8.1 Pregnancy Pregnancy Category X [see Boxed Warnings and Contraindications (4) ] Risk Summary POMALYST can cause embryo-fetal harm when administered to a pregnant female and is contraindicated during pregnancy. POMALYST is a thalidomide analogue. Thalidomide is a human teratogen, inducing a high frequency of severe and life-threatening birth defects such as amelia (absence of limbs), phocomelia (short limbs), hypoplasticity of the bones, absence of bones, external ear abnormalities (including anotia, micropinna, small or absent external auditory canals), facial palsy, eye abnormalities (anophthalmos, microphthalmos), and congenital heart defects. Alimentary tract, urinary tract, and genital malformations have also been documented and mortality at or shortly after birth has been reported in about 40% of infants. Pomalidomide was teratogenic in both rats and rabbits when administered during the period of organogenesis. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus. If pregnancy does occur during treatment, immediately discontinue the drug. Under these conditions, refer patient to an obstetrician/gynecologist experienced in reproductive toxicity for further evaluation and counseling. Report any suspected fetal exposure to POMALYST to the FDA via the MedWatch program at 1-800-FDA-1088 and also to Celgene Corporation at 1-888-423-5436. Animal Data Pomalidomide was teratogenic in both rats and rabbits in the embryo-fetal developmental studies when administered during the period of organogenesis. In rats, pomalidomide was administered orally to pregnant animals at doses of 25 to 1000 mg/kg/day. Malformations or absence of urinary bladder, absence of thyroid gland, and fusion and misalignment of lumbar and thoracic vertebral elements (vertebral, central, and/or neural arches) were observed at all dose levels. There was no maternal toxicity observed in this study. The lowest dose in rats resulted in an exposure (AUC) approximately 85-fold of the human exposure at the recommended dose of 4 mg/day. Other embryo-fetal toxicities included increased resorptions leading to decreased number of viable fetuses. In rabbits, pomalidomide was administered orally to pregnant animals at doses of 10 to 250 mg/kg/day. Increased cardiac malformations such as interventricular septal defect were seen at all doses with significant increases at 250 mg/kg/day. Additional malformations observed at 250 mg/kg/day included anomalies in limbs (flexed and/or rotated fore- and/or hindlimbs, unattached or absent digit) and associated skeletal malformations (not ossified metacarpal, misaligned phalanx and metacarpal, absent digit, not ossified phalanx, and short not ossified or bent tibia), moderate dilation of the lateral ventricle in the brain, abnormal placement of the right subclavian artery, absent intermediate lobe in the lungs, low-set kidney, altered liver morphology, incompletely or not ossified pelvis, an increased average for supernumerary thoracic ribs, and a reduced average for ossified tarsals. No maternal toxicity was observed at the low dose (10 mg/kg/day) that resulted in cardiac anomalies in fetuses; this dose resulted in an exposure (AUC) approximately equal to that reported in humans at the recommended dose of 4 mg/day. Additional embryo-fetal toxicity included increased resorption. 8.3 Nursing Mothers It is not known if pomalidomide is excreted in human milk. Pomalidomide was excreted in the milk of lactating rats. Because many drugs are excreted in human milk and because of the potential for adverse reactions in nursing infants from POMALYST, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. 8.4 Pediatric Use Safety and effectiveness of POMALYST in patients below the age of 18 years have not been established. 8.5 Geriatric Use No dosage adjustment is required for POMALYST based on age. Of the total number of patients in clinical studies of POMALYST, 44% were aged older than 65 years, while 10% were aged older than 75 years. No overall differences in effectiveness were observed between these patients and younger patients. In these studies, patients older than 65 years were more likely than patients less than or equal to 65 years of age to experience pneumonia. 8.6 Females of Reproductive Potential and Males POMALYST can cause fetal harm when administered during pregnancy [see Use in Specific Populations (8.1)]. Females of reproductive potential must avoid pregnancy while taking POMALYST and for at least 4 weeks after completing therapy. Females Females of reproductive potential must commit either to abstain continuously from heterosexual sexual intercourse or to use 2 methods of reliable birth control simultaneously: one highly effective form of contraception – tubal ligation, IUD, hormonal (birth control pills, injections, hormonal patches, vaginal rings, or implants), or partner’s vasectomy, and 1 additional effective contraceptive method – male latex or synthetic condom, diaphragm, or cervical cap. Contraception must begin 4 weeks prior to initiating treatment with POMALYST, during therapy, during dose interruptions, and continuing for 4 weeks following discontinuation of POMALYST therapy. Reliable contraception is indicated even where there has been a history of infertility, unless due to hysterectomy. Females of reproductive potential should be referred to a qualified provider of contraceptive methods, if needed. Females of reproductive potential must have 2 negative pregnancy tests before initiating POMALYST. The first test should be performed within 10-14 days, and the second test within 24 hours prior to prescribing POMALYST. Once treatment has started and during dose interruptions, pregnancy testing for females of reproductive potential should occur weekly during the first 4 weeks of use, then pregnancy testing should be repeated every 4 weeks in females with regular menstrual cycles. If menstrual cycles are irregular, the pregnancy testing should occur every 2 weeks. Pregnancy testing and counseling should be performed if a patient misses her period or if there is any abnormality in her menstrual bleeding. POMALYST treatment must be discontinued during this evaluation. Males Pomalidomide is present in the semen of males who take POMALYST. Therefore, males must always use a latex or synthetic condom during any sexual contact with females of reproductive potential while taking POMALYST and for up to 28 days after discontinuing POMALYST, even if they have undergone a successful vasectomy. Male patients taking POMALYST must not donate sperm. 8.7 Renal Impairment Pomalidomide and its metabolites are primarily excreted by the kidneys [see Clinical Pharmacology (12.3)]. The influence of renal impairment on the safety, efficacy, and pharmacokinetics of pomalidomide has not been evaluated. Patients with serum creatinine greater than 3.0 mg/dL were excluded in clinical studies. Avoid POMALYST in patients with a serum creatinine greater than 3.0 mg/dL. 8.8 Hepatic Impairment Pomalidomide is metabolized in the liver [see Clinical Pharmacology (12.3)]. The influence of hepatic impairment on the safety, efficacy, and pharmacokinetics of pomalidomide has not been evaluated. Patients with serum bilirubin greater than 2.0 mg/dL and AST/ALT greater than 3.0 x upper limit normal (ULN) were excluded in clinical studies. Avoid POMALYST in patients with serum bilirubin greater than 2.0 mg/dL and AST/ALT greater than 3.0 x ULN.

Save on the cost of Pomalyst

With Our Pomalyst Discount Card

Be sure to ask your pharmacist not to substitute another card for ours as we are confident we offer the highest savings possible.

Medication Discount Card Medication Discount Card
Frequently Asked Questions

There are no catches to this. Simply print the card, take it to your pharmacy, and save. If you still have questions just read below...

How Do I Know My Pharmacy Will Accept It?
That's simple. The card is accepted at ALL CHAIN PHARMACIES such as CVS, Rite Aid, and Walgreens. If you don't know if your pharmacy accepts the card simply call them and give them the BIN and PCN numbers on the card. The card is accepted at most pharmacies. If you call a few one is sure to accept it.
Can I Use This In Conjunction With My Insurance?
No, unfortunately insurance companies don't allow "double-savings". However, if your insurance does not cover certain drugs (ex - cosmetic drugs, brand names, prenatal vitamins, etc) then this card may save you money. Also if your insurance requires you to pay a deductible on your brand name drugs before covering them, then this card may also provider greater savings!
How Much Will This Card Save Me?
You can expect to save between 10% - 75% off standard retail pricing. The discount varies depending on what type and brand of drug (generic or brand-name) you are purchasing.
This Sounds Too Good To Be True. Is This A Scam?
Absolutely not. As you can see there are no fees, ever. We will never ask for credit card information at any time. The reason this card works is simply because pharmacies are willing to provide a discount in order to earn your business.
My Pharmacy Isn't Included. Can They Participate?
Yes! There are pharmacies who accept the pharmacy savings card that are not on our list. If you find one please email us and we'll update the list. If they are not a current partner and are interested, email us and we'll contact them to try and convince them to participate. You may also choose to call around and see if someone else in your area accepts it.
Is this the same as a Pomalyst copay card?
No this is not a copay card, It is good for the cash paying customer and cannot be used to reduce your copay.
Savings of 70%!
I want to thank you for your prescription card. My thyroid medicine was going to cost me $118 a month. Well, naturally, I thought of your card. Your site said for my 240 tablets a month it would be about $36. A savings of $82, or roughly 70%. Thank you for the relief your card has previously given to me now and in the past. - J. Donaldson
Savings of over $200!
Thank you for putting the medication discount card on the internet. I saved over 200 dollars On my prescription. I would have never been able to afford it had it not been for this product. Again I cannot thank you enough and keep up the good work!! - M. Axler
Savings of over 50%!
I had printed out 3 different discount cards on the internet and asked the pharmacist to check prices. The lowest price was $289. I searched the internet some more, I found this site, gave the pharmacy your card and the cost was $130. What a big savings, I can't thank this site enough. - Linda S.

Accepted at over 59,000 pharmacies nationwide including

Accepted At Over 59,000 Pharmacies Nationwide!

Including...
  • Including...
  • Cub Pharmacy
  • Kmart
  • HEB
  • Target
  • Winn Dixie
  • Costco
  • Safeway
  • Kroger
  • Tom Thumb
  • CVS
  • Brookshire`s
  • Rite Aid
  • Fred`s Pharmacy
  • Walmart
  • Long Drugs
  • Walgreens
  • Giant
  • Save Mart Pharmacy
  • Fred Meyer
  • We Care Pharmacy
  • Albertsons

And thousands of independent pharmacies nationwide!

Pomalyst Coupon

Currently we do not have any available, however you can receive an instant discount at your pharmacy with our Pomalyst discount card. Create one instantly

Important Note

The information on this website is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

This prescription discount card cannot be used in conjunction with insurance. However, some members find they save more when using the card rather than there prescription coverage.

This Pomalyst discount should not be confused with a Pomalyst coupon while they are essentially the same this discount card only needs to be handed to your pharmacist once and will provide continuous savings every time your prescription is filled. The only time you will need to use it again is if you change pharma

MedicationDiscountCard.com offers Average Savings of
60.04%
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  • Free Membership
  • No Health Restrictions
  • Use Immediately
  • Easy To Use
  • No Paperwork
  • Unlimited Use
  • Never Expires
"Thank you SO MUCH! My patients have saved so much money using these cards." - Danielle
Primary Care Coalition
primarycarecoalition.org
Save up to 75% on your medication
Save up to 75% on your medication